NCT02407197

International T1 Multicentre CMR Outcome Study

International T1 Multicentre CMR Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,629 (actual)
• Sponsor: King's College London · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Myocardial fibrosis is the fundamental substrate for the development of heart failure. Cardiovascular magnetic resonance (CMR) allows non-invasive assessment of myocardial fibrosis based on late gadolinium enhancement (LGE) and T1 mapping. Patients: Prospective longitudinal observational multicenter study of consecutive patients with suspected or known non-ischemic cardiomyopathy. Imaging: Non-invasive measures of myocardial fibrosis: native T1, extracellular volume fraction (ECV) and LGE. Primary endpoints: all cause and cardiovascular mortality. Secondary endpoints: arrhythmic composite and HF composite endpoints.

Conditions

• Cardiomyopathy
• Heart Failure
• Coronary Artery Disease
• Chronic Kidney Diseases
• Inflammation
• Fibrosis

Timeline

• Start date: 2011-01-01
• Primary completion: 2017-12-01
• Completion: 2022-12-01
• First posted: 2015-04-02
• Last updated: 2023-03-09

Locations

4 sites across 3 countries: Australia, Germany, United Kingdom