NCT02346812

Brassica Intake and Isothiocyanate Absorption

Brassica Intake and Isothiocyanate Absorption: Intake Patterns May Have Implications for Cancer Prevention by Dietary Brassica Vegetables

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: USDA Beltsville Human Nutrition Research Center · Federal
• Sex: All
• Age: 21 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Healthy individuals (n=18) will participate in 2 controlled-feeding study periods that are 3 weeks each in length: 1) Control diet 2) Brassica diet. The control diet will consist of typical American foods and will be free of Brassica vegetables and free of glucosinolates and isothiocyanates. The Brassica diet will contain the control diet plus glucosinolate/isothiocyanate treatment foods. There will be a break of 3 weeks in between study periods. Blood, urine, and fecal samples will be collected at the end of each study period. Eligible participants will be selected based on genotype for glutathione S-transferase (GST), which has been shown to influence the potential protective role of dietary Brassicas. Half the participants (n=9) will be GSTM1-positive individuals and half (n=9) will have the GSTM1-null genotype.

Conditions

• Healthy Volunteers

Interventions

Type	Name	Description
OTHER	Controlled diet without brassica vegetables	Participants will be fed a controlled diet containing foods of a typical American diet.
OTHER	Controlled diet with brassica vegetables	Participants will be fed a controlled diet containing foods of a typical American diet.

Timeline

• Start date: 2015-01-01
• Primary completion: 2015-04-01
• Completion: 2015-04-01
• First posted: 2015-01-27
• Last updated: 2015-04-30

Locations

1 site across 1 country: United States