NCT02335580

Effect of Portal Vein Thrombosis on the Prognosis of Liver Cirrhosis

Effect of Portal Vein Thrombosis on the Prognosis of Liver Cirrhosis: A Single-center, Prospective, Cohort Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 475 (actual)
• Sponsor: General Hospital of Shenyang Military Region · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The prevalence of portal vein thrombosis (PVT) in patients with liver cirrhosis is 5-20%. Current evidence regarding the effect of portal vein thrombosis on the prognosis of cirrhotic patients remains under debate. Considering that PVT potentially elevates the portal pressure and thereby increase the risk of variceal bleeding, we focus on the patients with high-risk varices and variceal bleeding as the study population. Thus, the main goals are to analyze the effect of PVT on the incidence of first variceal bleeding in patients without any prior bleeding history but with high-risk varices, the incidence of recurrent variceal bleeding in patients with a history of variceal bleeding, and the treatment failure rate of variceal bleeding in patients with acute variceal bleeding. Certainly, the survival is also observed in all patients.

Conditions

• Liver Cirrhosis
• Portal Vein
• Venous Thrombosis
• Varicose Veins
• Hemorrhage

Interventions

Type	Name	Description
DRUG	Somatostatin and its analogs	Somatostatin and/or octreotide will be intravenously infused.
PROCEDURE	Endoscopic sclerotherapy, endoscopic variceal ligation, endoscopic tissue glue injection	Endoscopic sclerotherapy, endoscopic variceal ligation, and/or endoscopic tissue glue injection will be performed based on the endoscopists' choice.

Timeline

• Start date: 2014-12-01
• Primary completion: 2022-12-01
• Completion: 2022-12-01
• First posted: 2015-01-12
• Last updated: 2023-02-24

Locations

1 site across 1 country: China