| Recruiting | The Influence of Laser Crossectomy With Different Wavelengths on Varicose Vein Progression NCT07449728 | Pirogov Russian National Research Medical University | N/A |
| Not Yet Recruiting | Polidocanol Foam With or Without Transdermal Laser for Varicose Veins: Randomized Clinical Trial NCT07276243 | Hospital Universitario Pedro Ernesto | N/A |
| Completed | First- or Second- Class Compression Hosiery After Endovenous Laser With Sclerotherapy and Ambulatory Phlebecto NCT06913764 | Moscow City Hospital named after A.K. Eramishantsev | N/A |
| Recruiting | Vacuum-assisted Laser Ablation (VALA) for Treatment of Large Saphenous Veins NCT06971068 | Center Of Phlebology | N/A |
| Not Yet Recruiting | Evaluating QoL and Postoperative Complications Using TEThA Technique in the Treatment of Tributary Veins NCT06669260 | Nara Medeiros Cunha de Melo Vasconcelos | — |
| Completed | Efficacy of the SALFOAM 3% Method Compared to the Conventional Polidocanol Foam Method (Tessari Method) for Tr NCT06667570 | Lidiane Rocha | N/A |
| Completed | REGIONAL ANESTHESIA AND RECOVERY AFTER VARICOSE VEIN RFA NCT07514000 | Zonguldak Bulent Ecevit University | — |
| Active Not Recruiting | Safety and Efficacy Of Amber Peripheral Liquid Embolic System NCT06456125 | LVD Biotech S.L | N/A |
| Completed | Effect Of Resistive Exercises Versus Aerobic Exercises On Varicose Veins In Postmenopausal Women NCT06271798 | Cairo University | N/A |
| Recruiting | THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE) NCT05735639 | Imperial College London | Phase 4 |
| Completed | Availability of Venous Conduits in Patients With Varicose Veins for Arterial Bypass Surgery NCT06332833 | Pirogov Russian National Research Medical University | — |
| Completed | A Study of Soundscapes for Patient Wellbeing NCT05650073 | Mayo Clinic | N/A |
| Unknown | Effect of Short-term Compression Therapy After Thermal Ablation for Varicose Veins NCT05840991 | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | N/A |
| Recruiting | Study on Treatment of Varicose Veins by Endovenous Laser (1940 nm vs 1470 nm) NCT05663359 | Clinique Pasteur | N/A |
| Terminated | Varithena Versus Endothermal Ablation of the Great Saphenous Vein (VERITAS) NCT05312970 | Boston Scientific Corporation | Phase 4 |
| Unknown | Comparison of Zero- and Two-centimeter Distance From Sapheno-femoral Junction in Laser Ablation of Varicose Ve NCT05707169 | Mansoura University | N/A |
| Completed | Quality of Life and Health Perception After Surgery of Varicose Veins NCT06290973 | Hospital Clínico Universitario de Valladolid | — |
| Completed | Microwaves Ablation of Varicose Veins NCT05508581 | Assiut University | N/A |
| Unknown | Comparison of Daytime Surgery in Varicose Veins Patients With and Without Superficial Venous Thrombosis NCT05380895 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Unknown | Radio Frequency Ablation Versus Stripping of Great Saphenous Vein in Management of Primary Varicose Veins , Co NCT05342779 | Sohag University | N/A |
| Completed | Varicose Vein Education and Informed coNsent (VVEIN) Study NCT05261412 | Royal College of Surgeons, Ireland | N/A |
| Unknown | High Intensity Focused Ultrasound in PAtients With Varicose Veins in Singapore NCT04339088 | Singapore General Hospital | — |
| Completed | The Evaluation of the Pathophysiology of Varicose Veins in Pregnancy NCT05058989 | Imperial College London | — |
| Unknown | Graduated Elastic compRession for vAricose Veins in PrEgnancy NCT05122195 | Belarusian State Medical University | — |
| Completed | Endovenous Radiofrequency Ablation Closure System in the Treatment of Varicose Veins NCT04671641 | Suzhou Hengruihongyuan Medical Technology Co. LTD | N/A |
| Active Not Recruiting | Varicose Vein in Patients Under the Age of 40 NCT05410912 | First Affiliated Hospital of Zhejiang University | — |
| Completed | Implementation of a Minor Ailment Service in Community Pharmacy Practice NCT05247333 | Universidad de Granada | N/A |
| Completed | Impact of Treatment With VENARUS® on the Level of Monocyte Chemoattractant Protein 1 in Varicose Veins Blood NCT04933591 | Pirogov Russian National Research Medical University | N/A |
| Unknown | Microwave Venous Ablation in Comparison to Radiofrequency Ablation, Laser Ablation and Surgical Ligation in Ma NCT04479956 | Mansoura University | N/A |
| Unknown | Efficacy and Safety of Endovenous Microwave Ablations for Treatment of Varicose Veins in Singapore NCT04524793 | Singapore General Hospital | N/A |
| Completed | Treatment of Insufficient Superficial and Perforatring Veins of the Lower Limb Using HIFU NCT04280679 | Theraclion | N/A |
| Unknown | The Prevstain Trial NCT04203043 | University of Sao Paulo General Hospital | Phase 2 |
| Active Not Recruiting | Elastic Compression Stockings and Varicose Veins Recurrence NCT04231942 | Pirogov Russian National Research Medical University | N/A |
| Unknown | Pathology, Venous Disease, and Clinical Correlations NCT04436549 | University of Catanzaro | — |
| Unknown | Lake Washington Vascular VenaSeal™ Post-Market Evaluation NCT04146168 | Lake Washington Vascular | — |
| Completed | Great Saphenous Vein Sparing Segmental Radiofrequency Ablation in Varicose Veins Patients NCT05372146 | Pirogov Russian National Research Medical University | N/A |
| Unknown | Registry to Investigate the Efficacy and Safety of VenaBlock VeIn SEaling System for VaRicose Veins in SingApo NCT04339075 | Singapore General Hospital | — |
| Unknown | Efficacy and Safety of Endovenous Radio Frequency (EVRF) for Treatment of Varicose Veins in Singapore NCT04384315 | Singapore General Hospital | — |
| Completed | Longitudinal or Transverse Orientation of Ultrasound Probe in Minimally Invasive Venous Surgery. NCT04036734 | National University of Ireland, Galway, Ireland | N/A |
| Completed | Retrospective Review of Saphenous Vein Incompetence: Venaseal Versus Endovenous Thermal Ablation NCT04006184 | Lake Washington Vascular | — |
| Completed | Treatment of Varicose Veins With the ELVeS® Radial® 2ring Slim Fiber. Are There Limitations? NCT03810677 | be Medical | — |
| Completed | Market Penetration of Laser Therapy in Venous Surgery: Ziekenhuis Oost-Limburg - Ziekenhuis Maas En Kempen Cen NCT03856814 | Duomed | — |
| Unknown | Compression Stockings Therapy Following Mechano-Chemical Ablation (Clarivein®) NCT03685838 | Singapore General Hospital | N/A |
| Unknown | MIcronized Flavonoid Fraction After MechanO-Chemical Ablation NCT04434274 | Belarusian State Medical University | — |
| Completed | Management of a Giant Lymphocele Following Varicose Vein Surgery - A Case Report NCT05398458 | Bahria International Hospital | — |
| Unknown | The Role of Pyroptosis in Chronic Venous Disease NCT03744858 | University of Catanzaro | — |
| Withdrawn | Hypnoanalgesia in Surgical and Endovenous Treatment of Varicosis NCT03601572 | University Hospital, Montpellier | — |
| Completed | Compression And Functional Ability After Endovenous Varicose Vein Treatment NCT03613376 | Oulu University Hospital | N/A |
| Completed | A Singapore Venaseal Real World Post-Market Evaluation Study NCT03893201 | Singapore General Hospital | — |
| Recruiting | Study of Foam Sclerotherapy Versus Ambulatory Phlebectomy NCT03416413 | Imperial College London | Phase 4 |
| Unknown | MechanO-Chemical Ablation Versus CompreSSion NCT04441957 | Belarusian State Medical University | — |
| Unknown | Ecchymosis and Coldness in Patients With Varicose Vein NCT03384355 | Vascular and Molecular Cardiology Society | — |
| Completed | New Compression Hosiery Versus Standard Class II Compression Stockings After Endothermal Ablation NCT03477227 | Pirogov Russian National Research Medical University | N/A |
| Completed | Mechanochemical Ablation Compared to Cyanoacrylate Adhesive NCT03392753 | Imperial College London | N/A |
| Completed | LivRelief Varicose Veins Cream in the Treatment of Varicose Veins NCT03653793 | Delivra, Inc. | N/A |
| Terminated | Embolization of Pelvic Varicosities in Patients With Pelvic Congestion Syndrome NCT03057067 | St. Olavs Hospital | N/A |
| Withdrawn | Effect of PEM Treatment of Superficial Axial and Tributary Vein Reflux on Improvement of Wound Healing in VLUs NCT02988063 | OhioHealth | Phase 4 |
| Completed | The Effect of Laser Power and Fiber Traction Speed on the Outcomes of Endovenous Laser Ablation NCT03037827 | Clinic of Phlebology and Laser Surgery, Chelyabinsk, Russia | N/A |
| Withdrawn | Endoveneous Histologic Study NCT03326219 | Rijnstate Hospital | N/A |
| Unknown | 3-4 Year Outcomes Following Endovenous Steam Ablation for Venous Insufficiency NCT02944331 | Lovisenberg Diakonale Hospital | — |
| Recruiting | Caprini Score in Venous Surgery: a Prospective Cohort Study NCT03041805 | Pirogov Russian National Research Medical University | — |
| Withdrawn | Efficacy of Vasculera in Prevention on Post-op Pain and Edema Following Lower Extremity Venous Treatment in th NCT02936271 | Corewell Health West | N/A |
| Unknown | Optimum Duration of Compression Stockings After Endovenous Varicose Vein Surgery NCT02676908 | St. James's Hospital, Ireland | N/A |
| Completed | Compression Therapy Following Truncal Vein Endothermal Ablation And Distal Sclerotherapy NCT02890563 | Oulu University Hospital | N/A |
| Completed | Primary Insufficiency of the GSV With a Diameter >/= 12 mm, Antero-lateral Branches, or Below the Knee NCT02345018 | Rijnstate Hospital | — |
| Completed | Venous Distension in Patients With Aneurysmatic Arterial Disease NCT02867501 | Kantonsspital Baselland Bruderholz | — |
| Completed | COmpressioN Following Endovenous TreatmenT of Incompetent Varicose Veins NCT02655406 | Imperial College London | N/A |
| Completed | DESIVI: Dosing of Electrical Stimulation in Venous Insufficiency NCT03850496 | Imperial College London | N/A |
| Terminated | Pilot RCT Evaluating a One Stop Vein Clinic NCT02557542 | Imperial College London | N/A |
| Completed | Copper Impact on Venous Insufficiency and Lipodermatosclerosis NCT03283800 | Croydon Health Services NHS Trust | N/A |
| Completed | Laser Ablation Versus Mechanochemical Ablation Trial NCT02627846 | Hull University Teaching Hospitals NHS Trust | Phase 4 |
| Completed | COMFORT: A Multicenter, Open-label, Randomized, Crossover Study NCT02462720 | Boston Scientific Corporation | Phase 4 |
| Completed | Compression Therapy Following Endothermal Ablation NCT02522845 | Imperial College London | N/A |
| Completed | Polidocanol Versus Glucose Treatment of Telangiectasia Trial NCT02657252 | UPECLIN HC FM Botucatu Unesp | Phase 4 |
| Completed | Estrogen Receptors and Chronic Venous Disease NCT02558426 | University of Catanzaro | — |
| Completed | Effect of Portal Vein Thrombosis on the Prognosis of Liver Cirrhosis NCT02335580 | General Hospital of Shenyang Military Region | — |
| Unknown | Long-term Ultrasound Guided Foam Sclerotherapy Versus Classical Surgical Stripping Study NCT02304146 | Maastricht University Medical Center | — |
| Completed | Trial of Radiofrequency Thermo-ablation Treatments of Great Saphenous Varicose Veins (3-RF Study) NCT02441881 | Worcestershire Acute Hospitals NHS Trust | N/A |
| Withdrawn | Safety And Efficacy Study Of Topic Mucopolysaccharide Polysulfate Cream In The Superficial Varicose Veins Trea NCT01426035 | EMS | Phase 3 |
| Withdrawn | Safety And Efficacy Study Of Topic Mucopolysaccharide Polysulfate In The Superficial Varicose Veins Treatment NCT01203397 | EMS | Phase 3 |
| Active Not Recruiting | Lower Limb Venous Insufficiency and the Effect of Radiofrequency Treatment Versus Open Surgery NCT02397226 | University Hospital, Linkoeping | N/A |
| Unknown | Great Saphenous Vein Electrocoagulation NCT02139085 | Instituto Dante Pazzanese de Cardiologia | Phase 2 |
| Unknown | RCT - Does Treating Incompetent Perforators Reduce Recurrence? NCT01949207 | The Whiteley Clinic | N/A |
| Completed | Outpatient Office Based Endovascular Procedures NCT04054440 | Methodist Health System | — |
| Completed | Treatment of Great Saphenous Vein Varicosities NCT05655416 | Al-Azhar University | N/A |
| Completed | REVITIVE for the Treatment of Patients With Venous Insufficiency NCT02114307 | Imperial College London | N/A |
| Unknown | Pelvic Embolisation to Reduce Recurrent Varicose Veins - Primary NCT01901731 | The Whiteley Clinic | N/A |
| Unknown | Pelvic Embolisation to Reduce Recurrent Varicose Veins - Recurrent NCT01909024 | The Whiteley Clinic | N/A |
| Completed | Clinical Investigation and Molecular Forms of Family Disease of Varicose NCT02870127 | Nantes University Hospital | — |
| Completed | Peripheral Vascular Disease and Nerve Stimulation NCT01942941 | Hull University Teaching Hospitals NHS Trust | N/A |
| Completed | Investigation Into the Pathophysiology and Treatment of Varicose Veins NCT06192472 | University of Surrey | N/A |
| Completed | Treatment of Saphenous Vein Reflux With 1920-nm Diode Laser NCT02504684 | Instituto Vascular BH | N/A |
| Completed | Comparison of Radiofrequency, Vein Stripping and CHIVA for Venous Insufficency NCT02454452 | Corporacion Parc Tauli | N/A |
| Unknown | PREservation Versus Thermal Ablation NCT04034329 | Belarusian State Medical University | — |
| Completed | Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins NCT02054325 | UPECLIN HC FM Botucatu Unesp | Phase 4 |
| Completed | Painless Local Infiltration Anesthesia NCT01611324 | Campus Bio-Medico University | Phase 4 |
| Completed | Clinical Trial of Endovenous 940 and 1470 Laser Ablation for Treating Great Saphenous Veins NCT01637181 | Erasmus Medical Center | N/A |
| Completed | Evaluation of Interventions to Improve Pain Relief, Perceived Anxiety and Recovery in Participants Receiving O NCT01508624 | University of Surrey | N/A |
| Completed | Rivaroxaban in Endovenous Laser Ablation With and Without Miniphlebectomy NCT02584842 | University Hospital, Basel, Switzerland | — |
| Completed | The Party Balloon Assisted Valsalva in Diagnosis of Superficial Venous Valvular Reflux of Lower Limb NCT02051439 | Mahidol University | N/A |
| Completed | Endovenous Radiofrequency Versus Laser Ablation for the Treatment of Great Saphenous Vein Reflux NCT02080013 | Ain Shams University | N/A |
| Completed | Pharmacokinetic Study of Polidocanol Endovenous Microfoam (PEM) NCT01428076 | Boston Scientific Corporation | Phase 1 |
| Unknown | A Comparison of Specialized Versus Standard Compression After Saphenous Ablation NCT01332838 | University of Washington | N/A |
| Completed | Prevalence of MTHFR Polymorphisms in Venous Disease NCT01993914 | Health Diagnostic Laboratory, Inc. | — |
| Completed | Efficacy and Safety Study of Polidocanol Injectable Foam for the Treatment of Saphenofemoral Junction (SFJ) In NCT01072877 | Boston Scientific Corporation | Phase 3 |
| Completed | Validity of Electronic Diary for Monitoring Varicose Veins Symptoms NCT01200199 | Boston Scientific Corporation | — |
| Completed | Polidocanol Endovenous Microfoam (PEM) Versus Vehicle for the Treatment of Saphenofemoral Junction (SFJ) Incom NCT01231373 | Boston Scientific Corporation | Phase 3 |
| Withdrawn | Comparison Study for Safety and Efficacy of Two Devices for the Treatment of the Great Saphenous Vein NCT01173419 | Angiodynamics, Inc. | N/A |
| Completed | Steam Ablation Versus Endovenous Laser Ablation for the Treatment of Great Saphenous Veins NCT02046967 | Erasmus Medical Center | N/A |
| Completed | An Open-label, Single-dose Pilot Study to Evaluate Varisolve® (Polidocanol Endovenous Microfoam (PEM)) 0.125% NCT00928421 | Boston Scientific Corporation | Phase 2 |
| Completed | Evaluation of Endovenous Sclerotherapy for Treatment of Varicose Veins NCT00954980 | University of Oklahoma | — |
| Completed | Randomized, Single Blind, Placebo Controlled, to Evaluate Efficacy and Safety of Polidocanol Injectable Foam f NCT00758420 | Boston Scientific Corporation | Phase 2 / Phase 3 |
| Terminated | The BRILLIANT Study NCT00618514 | Vascular Solutions LLC | N/A |
| Completed | Prospective Randomized Trial Comparing the New Endovenous Procedures Versus Conventional Surgery for Varicose NCT00621062 | Uppsala University | N/A |
| Unknown | Ambulatory Surgery of Lower Extremity Varicose Vein NCT00702897 | Far Eastern Memorial Hospital | — |
| Completed | Safety Study of Varisolve® Procedure for Treatment of Varicose Veins in Patients With Right-to-left Cardiac Sh NCT00442364 | Boston Scientific Corporation | Phase 2 |
| Completed | A Trial to Compare the Outcome of Localised Varicosity Compression for 24 Hours and 5 Days After Foam Scleroth NCT00991497 | Gloucestershire Hospitals NHS Foundation Trust | N/A |
| Completed | Juvista (Avotermin) in Scars Following Varicose Vein Removal NCT00430326 | Renovo | Phase 2 |
| Completed | Surgery Versus Sclerotherapy for Isolated Accessory Great Saphenous Vein Varicosis NCT02010723 | Medical University of Vienna | Phase 4 |
| Completed | Concomitant or Sequential Phlebectomy After Endovenous Laser Therapy for Varicose Veins NCT02017106 | Hull University Teaching Hospitals NHS Trust | N/A |
| Unknown | Endovenous Laser Therapy (EVLT) for Sapheno-Popliteal Incompetence and Short Saphenous Vein (SSV) Reflux: A RC NCT00841178 | Hull University Teaching Hospitals NHS Trust | N/A |
| Terminated | A Randomised Study to Assess Betadine in the Groin Wound of Patients Undergoing Primary Varicose Vein Surgery NCT00500669 | Royal Hobart Hospital | Phase 3 |
| Completed | A New Method of Surgically Treating Varicose Veins and Venous Ulcers - a Study to Assess Clinical and Economic NCT00759434 | Hull University Teaching Hospitals NHS Trust | N/A |
| Completed | The Long-term Value of Preoperative Duplex Before Surgery for Varicose Veins NCT01195623 | Uppsala University Hospital | N/A |