NCT02320240

Serotonin-norepinephrine Reuptake Inhibitors and Acute Kidney Injury

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 3,255,526 (actual)
• Sponsor: Canadian Network for Observational Drug Effect Studies, CNODES · Academic / Other
• Sex: All
• Age: 12 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if there is an excess risk of acute kidney injury (AKI) with Serotonin-norepinephrine reuptake inhibitors (SNRIs) as compared to Selective serotonin reuptake inhibitors (SSRIs), two classes of medication used for the treatment of depression.

Detailed description

We plan to conduct retrospective population-based cohort studies within eight administrative databases from Canada, the United States, and the United Kingdom. Within each cohort, a nested case-control analysis will be performed to estimate incidence rate ratios (RR) of AKI associated with SNRIs compared to SSRIs using conditional logistic regression, with adjustment for high-dimensional propensity scores at baseline. The overall effect across sites will then be estimated using meta-analytic methods.

Conditions

• Depression
• Acute Kidney Injury

Interventions

Type	Name	Description
DRUG	Duloxetine	Current exposure to Duloxetine will be defined as a prescription lasting until the index date or dispensed in the 60 days before the index date.
DRUG	Venlafaxine	Current exposure to Venlafaxine will be defined as a prescription lasting until the index date or dispensed in the 60 days before the index date.
DRUG	Desvenlafaxine	Current exposure to Desvenlafaxine will be defined as a prescription lasting until the index date or dispensed in the 60 days before the index date.
DRUG	Citalopram	Current exposure to Citalopram will be defined as a prescription lasting until the index date or dispensed in the 60 days before the index date.
DRUG	Escitalopram	Current exposure to Escitalopram will be defined as a prescription lasting until the index date or dispensed in the 60 days before the index date.
DRUG	Fluoxetine	Current exposure to Fluoxetine will be defined as a prescription lasting until the index date or dispensed in the 60 days before the index date.
DRUG	Fluvoxamine	Current exposure to Fluvoxamine will be defined as a prescription lasting until the index date or dispensed in the 60 days before the index date.
DRUG	Paroxetine	Current exposure to Paroxetine will be defined as a prescription lasting until the index date or dispensed in the 60 days before the index date.
DRUG	Sertraline	Current exposure to Sertraline will be defined as a prescription lasting until the index date or dispensed in the 60 days before the index date.

Timeline

• Start date: 2013-06-01
• Primary completion: 2014-12-01
• Completion: 2014-12-01
• First posted: 2014-12-19
• Last updated: 2016-03-14

Locations

1 site across 1 country: Canada