NCT02281695

PEEP Influence on Gas Exchange During Early Weaning

The Influence of Different PEEP Values on Gas Exchange in Spontaneously Breathing Patients During Early Weaning

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Marienhospital Osnabrück · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the differences in oxygenation and decarboxylation between two weaning processes.

Detailed description

First, during controlled mechanical ventilation all patients will be ventilated for 5 minutes with 100% oxygen. After 5 minutes an PaO2/FiO2 will be calculated and compared with a PaO2/FiO2 during ventilation with FiO2 - 30%. The patients will be divided in two sections: Section A are the patients with less than 24 hours mechanical ventilation until weaning start. Section B are the patients with more than 24 hours until weaning start. The patients in every section will be further divided in two groups. Group 1 will be weaned starting with a PEEP equal with P mean during BiPAP, Group 2 will be weaned starting with a PEEP equal with PEEP during BiPAP. Further, the weaning will be conducted after an known algorithm. The differences in the oxygenation and decarboxylation will be measured after 30 and 120 Minutes for Group A and after 30, 120, 240, 360 Minutes for Group B.

Conditions

• Respiratory Failure

Interventions

Type	Name	Description
OTHER	PEEP adjusment during the Weaning process	The PEEP will be adjusted after an previously established algorithm and the differences in the arterial blood oxygen partial pressure will be compared.

Timeline

• Start date: 2014-10-01
• Primary completion: 2018-11-01
• Completion: 2018-12-01
• First posted: 2014-11-03
• Last updated: 2022-09-01

Locations

1 site across 1 country: Germany