NCT02273128

A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis

Calcitonin Receptor Gene Polymorphisms in Patients With Osteoporosis and Chronic Periodontitis-An Observational Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 50 (actual)
• Sponsor: Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre · Academic / Other
• Sex: All
• Age: 35 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.

Detailed description

Periodontitis is a polymicrobial inflammatory disease which includes various modifiable and nonmodifiable risk factors. The non modifiable risk factors include genetic polymorphisms like metabolism associated genetic polymorphisms ( Vitamin D and Calcitonin). Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue with consequent increase in bone fragility and susceptibility to fractures. Bone loss is a common feature shared between periodontal disease and osteoporosis. Out of all genetic factors Calcitonin gene polymorphism contributes to the development of both osteoporosis and chronic periodontitis.

Conditions

• Generalized Chronic Periodontitis
• Osteoporosis

Interventions

Type	Name	Description
GENETIC	CTR Gene	2ml blood sample collected from patients to extract DNA for Assessment of CTR Gene polymorphism

Timeline

• Start date: 2014-06-01
• Primary completion: 2014-10-01
• Completion: 2014-11-01
• First posted: 2014-10-23
• Last updated: 2015-04-21

Locations

1 site across 1 country: India