NCT02273089

CPAP to Reduce Arterial Stiffness in Non Sleepy, Moderate to Severe Obstructive Sleep Apnea (STIFFSLEEP)

Use of CPAP to Reduce Arterial Stiffness in Moderate to Severe Obstructive Sleep Apnea, Without Excessive Daytime Sleepiness (STIFFSLEEP)

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 45 (actual)
• Sponsor: Centro Hospitalar de Lisboa Central · Academic / Other
• Sex: Male
• Age: 30 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study intends to determine whether continuous positive airway pressure (CPAP) can reduce arterial stiffness (measured by pulse wave velocity) in nonsleepy as well as in sleepy patients with obstructive sleep apnea .

Detailed description

Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and mortality. Arterial stiffness, evaluated by pulse wave velocity, is related to atherosclerosis and cardiovascular risk. It has been reported that arterial stiffness is higher in patients with OSA than in healthy control groups, and it is assumed that it decreases after treatment with CPAP. In patients with OSA without daytime hypersomnolence it is not clear if CPAP has some benefits on cardiovascular events and hypertension. This study aims to evaluate the effect of CPAP therapy in an interventional cohort of patients with moderate to severe OSA, in which each patient will be is own control, for ethical reasons; the effect of CPAP therapy on the subcohorts of sleepy and of nonsleepy patients will be compared. The effect of a three months trial of CPAP will be assessed.

Conditions

• Obstructive Sleep Apnea
• Vascular Stiffness
• Sleep Disorder Daytime Somnolence

Interventions

Type	Name	Description
DEVICE	CPAP (ResMed S9 AutoSet)	nocturnal CPAP for three months

Timeline

• Start date: 2012-10-01
• Primary completion: 2016-12-01
• Completion: 2017-06-01
• First posted: 2014-10-23
• Last updated: 2017-07-13

Locations

2 sites across 1 country: Portugal