NCT02267980

Effect of the Addition of Ketamine to Sevoflurane Anesthesia in Electroconvulsive Therapy

Turgut Ozal Medical Center Department of Anesthesiology and Reanimation

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Inonu University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The investigators evaluate the effects of a subanesthetic dose of ketamine, administered as an adjunct to sevoflurane, on duration of seizure activity, hemodynamic profile and recovery times during electroconvulsive therapy (ECT) in patients with major depression.

Detailed description

Patients will randomly allocate, to either a sevoflurane-ketamine (Group SK), sevoflurane-saline (Group SS) receiving group. Mean arterial pressure (MAP) and heart rate (HR) will record prior to anesthetic induction (T1); following anesthetic induction (T2); and 0, 1, 3, and 10 min after the seizure has ended (T3, T4, T5, and T6, respectively). Motor and EEG seizure durations will be recorded.

Conditions

• Depressive Disorder

Interventions

Type	Name	Description
DRUG	Sevoflurane	Inhalation anesthetic agent
DRUG	Ketamine	Intravenous anesthetic agent
DRUG	Saline	Isotonic solution for placebo group

Timeline

• Start date: 2014-07-01
• Primary completion: 2014-10-01
• Completion: 2014-10-01
• First posted: 2014-10-20
• Last updated: 2014-10-20

Locations

1 site across 1 country: Turkey (Türkiye)