NCT02265562

Rectal Misoprostol and Blood Loss During Abdominal Hysterectomy

Evaluation of the Effect of Rectal Misoprostol on Blood Loss During Abdominal Hysterectomy: A Double Blind Randomized Controlled Trial.

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 220 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: Female
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Hysterectomy, as any major operation, can cause complications, as hemorrhage which may occur in some cases and sometimes requiring blood transfusion. Recent study proved that misoprostol success in reducing blood loss during total abdominal hysterectomy when used once before the surgery.

Detailed description

In this study we tried to assess the efficacy of misoprostol in minimize blood loss during hysterectomy when used as single preoperative dose via rectal route. The reduction of blood flow may be due to the combined effect of myometrial contraction and vasoconstrictive effect

Conditions

• Blood Loss

Interventions

Type	Name	Description
DRUG	Misoprostol	60 minutes before the surgery 400 μg of misoprostol (2 tablets of 200 μg) inserted rectally
DRUG	Placebo	60 minutes before the surgery 2 tablet of placebo inserted rectally

Timeline

• Start date: 2014-10-01
• Primary completion: 2015-05-01
• Completion: 2015-06-01
• First posted: 2014-10-16
• Last updated: 2014-10-16

Locations

1 site across 1 country: Egypt