NCT02256540

The Effects of Resveratrol and Acute Exercise on Endothelial Function in Postmenopausal Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: Female
• Age: 50 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This pilot study plans to learn more about the aging of blood vessels and arteries in women. As women age and go through menopause, their risk for cardiovascular disease increases. Also with aging and menopause, levels of the reproductive hormone estradiol decline. Hormone replacement therapy to restore estradiol levels does not protect women from cardiovascular disease, so lifestyle changes, such as regular exercise, are recommended to reduce disease risk. However, there are differences between men and women in their response to exercise. In older men, exercise improves the health of their arteries, but in postmenopausal women, exercise does not provide this benefit. The purpose of this pilot study is to determine whether low estradiol levels in postmenopausal women are responsible for the poor vascular response to exercise. In this study the investigators will also test whether treatment with resveratrol, a plant compound found in red wine, improves postmenopausal women's response to exercise. The investigators hypothesize that acute treatment with estrogen or resveratrol will improve vascular responses to an acute bout of exercise.

Conditions

• Endothelial Dysfunction

Interventions

Type	Name	Description
DRUG	Climara
DRUG	Placebo patch	Placebo patch designed to match active Climara patches.
DIETARY_SUPPLEMENT	Resveratrol
DIETARY_SUPPLEMENT	Placebo	Placebo tablets designed to match active resveratrol tablets.

Timeline

• Start date: 2014-08-01
• Primary completion: 2016-03-25
• Completion: 2016-03-25
• First posted: 2014-10-03
• Last updated: 2020-03-20
• Results posted: 2020-03-20

Locations

1 site across 1 country: United States