NCT02253732

Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Slovak Academy of Sciences · Other Government
• Sex: All
• Age: 60 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction. Next the investigators would like to determine the shift in the muscle secretory activity induced by regular exercise intervention, which the investigators think could be translated into the beneficial changes in clinical phenotypes, determined by neuroimaging, cognitive function tests and metabolic phenotyping.

Detailed description

Standard Operating Procedures for patient recruitment, data collection, data management, data analysis routinely used in University Hospital Bratislava and in Institute of Experimental Endocrinology Slovak Academy of Sciences will be employed. Statistical analysis will be employed to address the primary and secondary objectives, as specified in the study protocol.

Conditions

• Mild Cognitive Impairment
• Alzheimer Disease
• Parkinson Disease
• Healthy Volunteers

Interventions

Type	Name	Description
BEHAVIORAL	3 months exercise intervention program	3 months exercise intervention program which is given 3-times per week, 60 min session duration, 65-75% repetition maximum or heart rate maximum, combined strength \& aerobic exercises

Timeline

• Start date: 2015-09-01
• Primary completion: 2017-09-01
• Completion: 2018-03-01
• First posted: 2014-10-01
• Last updated: 2018-04-17

Locations

2 sites across 1 country: Slovakia