NCT02243254

Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Postoperative hyperalgesia has been reported after intraoperative administration of small or high-dose remifentanil. Cyclooxygenase inhibitor exhibit preventive effects on the development of opioid-induced hyperalgesia. The aim of this study is to evaluate the preventive effect of intravenous ibuprofen (Caldolor®) on remifentanil-induced hyperalgesia

Conditions

• Ibuprofen
• Remifentanil
• Hyperalgesia
• Pain, Postoperative

Interventions

Type	Name	Description
DRUG	high dose remifentanil	high dose remifentanil
DRUG	Ibuprofen	intravenous ibuprofen
DRUG	low dose remifentanil	low dose remifentanil

Timeline

• Start date: 2014-07-01
• Primary completion: 2015-04-01
• First posted: 2014-09-17
• Last updated: 2015-11-18

Locations

1 site across 1 country: South Korea