NCT02230839

Muscle Insulin Resistance in Aging (Mirage)

Muscle Insulin Resistance In Aging

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: AdventHealth Translational Research Institute · Academic / Other
• Sex: All
• Age: 65 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to provide information regarding potential factors underlying metabolic dysfunction, insulin resistance, and loss of muscle mass in aging muscle.

Detailed description

Study Objectives: 1. To determine the effects of diet-induced weight loss with and without the addition of exercise on mitochondrial biogenesis and energetic capacity, cellular redox state and insulin resistance. 2. To determine the effects of diet-induced weight loss with and without the addition of exercise on intramyocellular lipid profiles. 3. To determine the effects of diet-induced weight loss with and without exercise on skeletal muscle proteins mediating a program of autophagy and either loss or maintenance of muscle mass.

Conditions

• Insulin Resistance
• Sarcopenia

Interventions

Type	Name	Description
BEHAVIORAL	Exercise	Participants will complete a progressive 6-month exercise training program, 4-5 days per week, 45 min per session (180 min per week), consisting mostly of walking (both outside and on an indoor treadmill) but with the option to include stationary cycling, elliptical and rowing machines, similar to what we have utilized previously to elicit significant improvements in insulin sensitivity in both middle-age and older adults (52-55). Beginning at week 8, these subjects will also perform 2 non-consecutive resistance exercise sessions per week, 30 min per session, focused on major muscle groups using resistance machines (total days of exercise will still be 4 to 5).
BEHAVIORAL	Energy Restriction-Induced Weight Loss	The goal of the weight loss intervention will be to produce a weight loss of 10% body weight. A reduction of 500-1000 kcal/day - based on baseline weight -and low fat (\<30% of calories from fat) diet will be used as part of the weight loss intervention.

Timeline

• Start date: 2014-06-01
• Primary completion: 2023-12-31
• Completion: 2025-12-01
• First posted: 2014-09-03
• Last updated: 2025-08-03

Locations

1 site across 1 country: United States