NCT02230358

Cardiac Output and Duplex Sonography in Carotid Endarterectomy

Cardiac Output and Cerebral Blood-flow During Carotid Endarterectomy in Regional vs. General Anesthesia. A Prospective Randomized Controlled Single Center Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Medical University Innsbruck · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to investigate the differences between the cardiac output and the cerebral blood-flow between a regional anesthesia (RA) and a general anesthesia (GA) in a randomized, controlled, single center study at the Medical University Innsbruck, Department of Anesthesia and Intensive Care Medicine.

Detailed description

The investigators will investigate the differences between the cardiac output and the cerebral blood-flow between a regional anesthesia (RA) and a general anesthesia (GA) in a randomized, controlled, single center study at the Medical University Innsbruck, Department of Anesthesia and Intensive Care Medicine. For this purpose patients with the need of a carotid endarterectomy (CEA) will be included and randomized either to the regional anesthesia (RA) or the general anesthesia (GA) group until a patient number of 45 in each group is achieved. The cardiac output and cerebral blood-flow via trans-cranial Doppler (TCD) will be measured at 6 time points: * T0 Baseline (after insertion of an arterial line) * T1 After induction of anesthesia, but before surgical start * T2 Two minutes after clamping the carotid artery * T3 Two minutes after shunt insertation of the carotid artery * T4 After reperfusion * T5 After completion of the skin suture

Conditions

• Carotid Stenosis

Interventions

Type	Name	Description
PROCEDURE	Regional anesthesia	Regional anesthesia
PROCEDURE	General anesthesia	General anesthesia
DEVICE	Transcranial Doppler ultrasonography	6x for 4 hours
PROCEDURE	blood gas analysis	6 x 3 ml blood withdrawal (18 ml) within 4 hours
PROCEDURE	invasive arterial blood pressure measurement	before operation, 8 hours, as done in clinical routine
PROCEDURE	arterial blood gas measurement	perioperative, 4-6 times within 8 hours, as done in clinical routine
BEHAVIORAL	Neurological Control	perioperative, 2-3 days, as done in clinical routine
BEHAVIORAL	NIRS monitoring	perioperative, for 5 hours, as done in clinical routine
DEVICE	oxygen supply (not invasive 'Vigileo')	perioperative for 5 hours, as done in clinical routine

Timeline

• Start date: 2014-07-01
• Primary completion: 2017-07-01
• Completion: 2017-07-01
• First posted: 2014-09-03
• Last updated: 2021-09-13

Locations

1 site across 1 country: Austria