NCT02213341

Impact of Vaccination on Th2 Immunity in Infancy

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 77 (actual)
• Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) · NIH
• Sex: All
• Age: 5 Months – 7 Months
• Healthy volunteers: Accepted

Summary

The purpose of this study is to assess the responses in the immune system of infants after they receive the vaccine against diphtheria, tetanus, and pertussis (DTaP). The investigators will do this by studying the immune cells and allergy responses in the blood prior to and after receipt of the third DTaP vaccine.

Detailed description

This is a single-site study of infants who are scheduled to receive their third series (\~6 month) vaccinations, as routine care, to investigate whether the diphtheria, tetanus, and pertussis (DTaP) vaccination has an effect on specific immunoglobulin E (IgE) levels to milk, egg, or peanut. Infants will be assigned to one of two groups depending on the infant's sensitization to milk, egg, and peanut.

Conditions

• Food Hypersensitivity

Interventions

Type	Name	Description
PROCEDURE	Skin prick allergen test	To test for hypersensitivity to milk, egg, or peanut
PROCEDURE	Blood draw

Timeline

• Start date: 2015-01-01
• Primary completion: 2016-06-14
• Completion: 2016-06-14
• First posted: 2014-08-11
• Last updated: 2019-07-23

Locations

1 site across 1 country: United States