NCT02210169

RCT of Continuous Versus Intermittent Infusion of Vancomycin in Neonates

A Randomised Controlled Trial (RCT) of Continuous and Intermittent Infusion of Vancomycin in Neonates

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 111 (actual)
• Sponsor: Murdoch Childrens Research Institute · Academic / Other
• Sex: All
• Age: 90 Days
• Healthy volunteers: Not accepted

Summary

Babies aged 0 to 90 days with a suspected infection requiring treatment with vancomycin will be recruited. They will be randomised to receive vancomycin as an intermittent infusion (over 1 hour) or as a continuous infusion (over 24 hours). The hypothesis is that administering vancomycin as a continuous infusion will result in improved attainment of target concentrations in blood at steady state (when the drug is in equilibrium) compared to intermittent infusion.

Conditions

• Sepsis
• Infection
• Bacteremia

Interventions

Type	Name	Description
DRUG	Continuous infusion of vancomycin	Continuous infusion of vancomycin will be given as a loading dose over 1 hour then as a continuous infusion over a 24-hours period.

Timeline

• Start date: 2014-09-01
• Primary completion: 2018-04-01
• Completion: 2018-05-01
• First posted: 2014-08-06
• Last updated: 2018-11-02

Locations

2 sites across 1 country: Australia