NCT02185209

Surgical Treatment of Peri-implantitis With and Without Systemically Adjunctive Antibiotics

Surgical Treatment of Peri-implantitis With and Without Systemically Adjunctive Antibiotics A Prospective, Double Blind, Randomized, Three Armed, Parallel, Placebo Controlled Clinical Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 77 (actual)
• Sponsor: Margareta Hultin · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate if the use of systemic adjunctive antibiotics in the treatment of periimplantitis is needed.

Detailed description

This study will give the opportunity to draw scientifically based conclusions on the recommendations of the use of adjunctive systemic antibiotics in the treatment of peri-implantitis. This study will also be able to determine the ecological impact on the oropharyngeal and intestinal microflora between different antibiotic treatments. The lack of knowledge in this area has been highlighted by the Food and Drug Administration and The Swedish Council on Health Technology Assessment (SBU)

Conditions

• Periodontal Diseases
• Periimplantitis

Interventions

Type	Name	Description
DRUG	Placebo	Place capsule to mimic antibiotics
DRUG	Amoxicillin Sandoz	Tablet 500 mg amoxicillin Sandoz three times a day
DRUG	Metronidazole Sanofi	400 mg metronidazole Sanofi administered three times a day (TID)
DRUG	Phenoxymethylpenicillin Meda	1600 mg phenoxymethylpenicillin Meda, three time a day (TID)

Timeline

• Start date: 2015-03-01
• Primary completion: 2022-05-27
• Completion: 2022-05-27
• First posted: 2014-07-09
• Last updated: 2022-08-18

Locations

2 sites across 1 country: Sweden