NCT02181491

PET Imaging in Cocaine Self Administration

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

There has been recent interest in the role of the 5-HT1B receptor as a possible modulating factor in cocaine dependence, certainly in preclinical models. The Yale Positron Emission Tomography (PET) Center has developed a novel 5-HT1B receptor antagonist radioligand, \[11C\]-P943, which has been validated in human studies. We hypothesize that the 5-HT1B receptor plays a key role in cocaine dependence. The long term goal of this project would be to study pharmacological manipulation of the 5-HT1B receptor as a potential molecular target for cocaine dependence.

Conditions

• Cocaine Dependence

Interventions

Type	Name	Description
OTHER	[11C]-P943

Timeline

• Start date: 2014-07-01
• Primary completion: 2019-12-01
• Completion: 2019-12-01
• First posted: 2014-07-04
• Last updated: 2020-11-19

Locations

1 site across 1 country: United States