NCT02141620

n-Acetylcysteine and Cocaine

Motivation for Cocaine and Non-Drug Reinforcers: Targeting Glutamate Homeostasis

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of Kentucky · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence. A rigorous, inpatient human laboratory study will be conducted in which the subjective, physiological and reinforcing effects of cocaine are evaluated during maintenance on placebo and n-acetylcysteine.

Conditions

• Cocaine Abuse
• Cocaine Dependence

Interventions

Type	Name	Description
DRUG	Cocaine	The pharmacodynamic effects of cocaine will be determined during maintenance on placebo and n-acetylcysteine.
DRUG	n-Acetylcysteine
DRUG	Placebo

Timeline

• Start date: 2014-05-01
• Primary completion: 2016-04-01
• Completion: 2016-04-01
• First posted: 2014-05-19
• Last updated: 2017-01-04
• Results posted: 2016-10-06

Locations

1 site across 1 country: United States