Trials / Completed
CompletedNCT02126969
A Study of Chemo +/- Low-dose Radiation as Induction Therapy in SCCHN
A Phase II Study of Docetaxel, Carboplatin With and Without Low Dose Radiation as Induction Therapy in Locally Advanced Head and Neck Cancer
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 45 (actual)
- Sponsor
- Susanne Arnold · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The primary hypothesis of this study is that hyper-radiosensitivity (HRS) seen at extremely low doses of radiation can be exploited to enhance the effect of chemotherapy, and that this effect differs from the cellular effect of higher, standard fractions of radiation used in traditional radiation treatment paradigms.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| RADIATION | Low dose fractionated radiation - 80cGy with chemotherapy | Chemotherapy + 80 cGy of RT |
| DRUG | Docetaxel and Carboplatin AUC 6 | Docetaxel 75 mg/m2 and Carboplatin AUC 6 without Radiation |
Timeline
- Start date
- 2014-10-01
- Primary completion
- 2018-03-01
- Completion
- 2021-06-15
- First posted
- 2014-04-30
- Last updated
- 2023-03-13
- Results posted
- 2019-06-20
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02126969. Inclusion in this directory is not an endorsement.