NCT02118519

Mesenchymal Stem Cells in Knee Cartilage Injuries

Use of Mesenchymal Stem Cells for the Repair of Articular Cartilage Disorder of Knee Using Intra-articular Injection of Mesenchymal Cells Alone or Mesenchymal Cells With Platelet Lysate

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: University of Jordan · Academic / Other
• Sex: All
• Age: 40 Years – 68 Years
• Healthy volunteers: Not accepted

Summary

Induction of autologous repair chondrogenesis to regenerate injured articular cartilage using bone marrow mesenchymal stem cells (MSCs) after in vitro expansion under restricted culturing conditions.

Detailed description

Fourteen patients from both genders, age range 40-68, will be enrolled according to strict inclusion and exclusion criteria, divided into two equal groups based upon receiving autologous MSCs alone, or MSCs supported by platelet lysate through percutaneous injection. The patients are followed by clinical assessment, laboratory investigations as well as magnetic resonance imaging (MRI) of the injected knee. The investigators hypothesize that the two groups will give satisfactory clinical outcomes, but the investigators are looking forward to assessing the best product that will activate chondrogenesis and heal cartilaginous injury.

Conditions

• Articular Cartilage Disorder of Knee
• Osteoarthritis, Knee

Interventions

Type	Name	Description
BIOLOGICAL	Autologous Mesenchymal Stem Cells	Comparison of clinical outcomes of patients injected by mesenchymal stem cells only with patients injected with mesenchymal stem cells supported by platelet lysate

Timeline

• Start date: 2014-01-01
• Primary completion: 2015-08-01
• Completion: 2015-08-01
• First posted: 2014-04-21
• Last updated: 2016-02-24

Locations

1 site across 1 country: Jordan