NCT02117726

Impact of Various Sedation Regimens on the Incidence of Delirium

Impact of Various Sedation Regimens on the Incidence of Post-sedation Delirium in Patients Receiving Mechanical Ventilation

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 320 (estimated)
• Sponsor: Shandong Provincial Hospital · Other Government
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Sedation drugs that are commonly used in ICU in treatment of ARDS, includes propofol, midazolam and dexmedetomidine . Among these, both dexmedetomidine and propofol have been reported to be used together with midazolam in ICU and the combination of propofol and midazolam is most commonly used, but things follow include a high incidence rate of delirium, But the combination of midazolam and dexmedetomidine may have complementary advantages and could have be a better choice for sedation. In this study, we attempted to observe the effects of two different drug regimens on delirium incidence rates in severe ARDS patients' : midazolam and propofol vs propofol and dexmedetomidine .

Conditions

• Delirium

Interventions

Type	Name	Description
DRUG	Dexmedetomidine,midazolam
DRUG	Propofol,midazolam

Timeline

• Start date: 2014-05-01
• Primary completion: 2015-12-01
• First posted: 2014-04-21
• Last updated: 2014-07-16

Locations

7 sites across 1 country: China