NCT02116400

Neuropsychological Characterization of Patients With Bipolar Disorder and a History of Suicide Attempt

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nīmes · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The main objective of this study is to evaluate decision-making using the Iowa Gambling Task (IGT) among patients with euthymic bipolar disorder according to their personal history of suicide attempt ("suicidal" vs. "not suicidal ").

Detailed description

The secondary objectives of this study are: A. Evaluate other aspects of cognitive functioning (using the Tower of London, the Probabilistic Reversal-learning task, the Rey Complex Figure, the Reading the Mind in the Eyes test) in euthymic patients with bipolar disorder, depending on the presence or absence of a history of suicide attempt; B. Explore performance on neuropsychological tests depending on the type of therapy administered (lithium salts or valproate monotherapy or in combination with other mood stabilizers); C. Explore a possible relationship between circulating levels of lithium or sodium divalproex results and different neuropsychological tests; D. Establishment of a biobank for this population with leftover blood samples following serum lithium or divalproex testing.

Conditions

• Bipolar Disorder

Interventions

Type	Name	Description
OTHER	Interview	All patients are interviewed at the BEC. Questionnaires and scores are administered. See endpoints.
OTHER	Neuropsychological testing	Neuropsychological tests are administered (requires computer use). See endpoints.
BIOLOGICAL	Serum concentration of lithium or sodium divalproate.	Venous blood is drawn and tested for serum concentration of lithium or sodium divalproate.

Timeline

• Start date: 2017-01-01
• Primary completion: 2018-07-01
• Completion: 2018-07-01
• First posted: 2014-04-16
• Last updated: 2016-05-24