NCT02114619

Comparative Study of Different I-131 Doses in Graves' Disease

The Effect of Different Calculated Doses of I-131 in Treatment of Patients With Grave's Disease

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 450 (estimated)
• Sponsor: Mashhad University of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Radioactive iodine (RAI) administration is an effective and completely established treatment modality in hyperthyroidism including Graves' disease. Despite the long experience with radioiodine for hyperthyroidism, controversy remains regarding the optimal dose of iodine that is required to achieve long-term euthyroidism. The fixed activity administration method does not optimize the therapy, giving often too high or too low radiation to the gland, but the optimal dose per gram of thyroid mass in calculated activity administration method is also under much debates. This prospective study has been designed in order to compare the effect of different calculated doses of radioiodine on Graves' disease treatment outcome.

Conditions

• Graves' Disease

Interventions

Type	Name	Description
DRUG	Low dose of I-131	We wil administer 100 micro currie of iodine per thyroid gram
DRUG	Intermediate dose	We will administer 150 micro currie of iodine per thyroid gram
DRUG	High dose	We will administer 200 micro currie of iodine per thyroid gram

Timeline

• Start date: 2013-05-01
• Primary completion: 2014-12-01
• Completion: 2016-12-01
• First posted: 2014-04-15
• Last updated: 2014-04-15

Locations

1 site across 1 country: Iran