NCT02098096

Negative Work Exercise for the Treatment of Knee Arthritis

Development of a Negative Work Exercise Regimen as an Intervention for Posttraumatic Osteoarthritis of the Knee

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 54 (actual)
• Sponsor: Washington D.C. Veterans Affairs Medical Center · Federal
• Sex: Male
• Age: 50 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to develop a negative work exercise regimen as an intervention for posttraumatic osteoarthritis (PTOA). "Negative work" is the force produced by muscles as they lengthen, and regularly occurs with common activities such as lowering an object from a shelf or walking down stairs. In this study, the investigators are examining the effectiveness of negative work exercise over a 12-week period in older, male, Veterans.

Detailed description

Purpose: To develop a negative work exercise regimen as an intervention for posttraumatic osteoarthritis (PTOA). Given that the medical management of chronic PTOA is similar to idiopathic OA, the investigators propose a randomized, clinical trial to pilot negative work exercise in Veterans with knee OA as a proof-of-concept study for a subsequent investigation for people with PTOA. Research Setting: DC VAMC, Physical Medicine \& Rehabilitation Laboratory Participants: Men between the ages of 50 and 70 years with a history of bilateral knee osteoarthritis will be consecutively recruited from the DC VAMC Rheumatology Service, Geriatrics Service, and Primary Care Medical Service. Implications/Significance: The use of negative work exercise to enhance the force attenuation properties of muscle is an innovative approach to the treatment of OA and PTOA, and represents a significant departure from previous rehabilitation studies concerning arthritis. Use of a negative work paradigm may prove to be beneficial for older Veterans with OA and active military personnel with PTOA since similar muscle mechanics are involved in the energy absorption at the knee joint during gait. Despite the functional importance of lengthening muscle actions in protecting weight-bearing joints affected by arthritis, the authors are not aware of a study that involves the sole use of a negative work intervention for OA or PTOA. Addressing the aims of this proposal would lay the ground work needed to justify larger clinical trials featuring the negative work paradigm for soldiers with PTOA.

Conditions

• Osteoarthritis
• Arthritis

Interventions

Type	Name	Description
OTHER	Negative Work	Exercise will be performed twice per week for 12 weeks and exercise intensity will be progressed in three phases. These phases are: 1. Familiarization 2. Acclimatization 3. Progression Exercise volume will be 3 sets of 10 repetitions (progressing to 4 sets at Week 6) for the knee flexors and extensors. All exercise will be supervised by a physical therapist and performed on a Biodex isokinetic dynamometer.
OTHER	Stretching	Home exercise program will be performed by the Placebo Comparator group and feature stretching over the 12 week intervention period.

Timeline

• Start date: 2014-03-01
• Primary completion: 2017-10-01
• Completion: 2019-11-01
• First posted: 2014-03-27
• Last updated: 2018-09-20

Locations

1 site across 1 country: United States