Trials / Terminated
TerminatedNCT02095639
Inflammation and Electroconvulsive Therapy
Does Electroconvulsive Therapy Cause Neuroinflammation? An [18F]FEPPA Positron Emission Tomography Study in Treatment Resistant Depression
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 5 (actual)
- Sponsor
- Centre for Addiction and Mental Health · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to explore whether electroconvulsive therapy (ECT) accidentally leads to a side effect of brain inflammation. Patients with treatment resistant depression who are planning to take ECT will be subsequently approached to participate in the study.
Detailed description
The first scan will take place before the first ECT session. The second scan will occur after a minimum of six ECT sessions (average 2.5 weeks). Secondary measures will include mood symptom severity, neurocognitive measures, peripheral inflammatory markers and TSPO genotype. The hypothesis is that neuroinflammation will be increased by ECT. There will be no alterations to standard care of depressed patients due to participation in the study.
Conditions
Timeline
- Start date
- 2012-08-01
- Primary completion
- 2017-03-01
- Completion
- 2017-05-01
- First posted
- 2014-03-26
- Last updated
- 2018-02-14
Locations
1 site across 1 country: Canada
Source: ClinicalTrials.gov record NCT02095639. Inclusion in this directory is not an endorsement.