Trials / Completed
CompletedNCT02080832
Brain Function and Structure in Cocaine Dependence
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 54 (actual)
- Sponsor
- Virginia Commonwealth University · Academic / Other
- Sex
- All
- Age
- 18 Years – 50 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to examine the role of brain MRI findings in predicting treatment outcomes among individuals with cocaine dependence.
Detailed description
The Specific Aims of this project are: Aim 1: To determine whether pretreatment brain activation on fMRI while performing a Go-Nogo task predicts response to pharmacotherapy in cocaine dependent subjects. Hypothesis related to Aim 1: Pretreatment fMRI BOLD activation in cocaine dependent subjects during impulsive responding on the Go-Nogo task predicts 8-week outcome from medication known to enhance serotonin function (citalopram). The regression coefficient of TES on pretreatment mean BOLD activation on the Go-Nogo task will be significantly greater for the citalopram group than the placebo group. Aim 2: To determine whether pretreatment brain activation on fMRI while performing an attentional bias (cocaine Stroop) task predicts response to pharmacotherapy in cocaine dependent subjects. Hypothesis related to Aim 2: Pretreatment fMRI BOLD activation in cocaine dependent subjects during cocaine related words on the cocaine Stroop task predicts 8-week outcome from medication known to enhance serotonin function (citalopram). The regression coefficient of TES on pretreatment mean BOLD activation from the cocaine Stroop task will be significantly greater for the citalopram group than the placebo group.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Citalopram | 20 mg or 40 mg daily for 8 weeks |
| DRUG | Placebo | Placebo daily for 8 weeks |
Timeline
- Start date
- 2010-02-01
- Primary completion
- 2016-02-01
- Completion
- 2016-02-01
- First posted
- 2014-03-06
- Last updated
- 2017-12-26
- Results posted
- 2017-12-26
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02080832. Inclusion in this directory is not an endorsement.