NCT02078778

Central and Peripheral Blood Pressure in Treatment of Obstructive Sleep Apnea.

Central and Peripheral 24-h Blood Pressure Monitoring in Patients With Hypertension and Obstructive Sleep Apnea Before and After Treatment With Continuous Positive Airway Pressure.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Erling Bjerregaard Pedersen · Academic / Other
• Sex: All
• Age: 55 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the effect on blood pressure of 3 months of treatment with continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea (OSA). Hypothesis: 1. Central 24-h blood pressure (BP) monitoring hedges day fluctuations in blood pressure more accurately than peripheral 24-h BP monitoring, because the measurement is painless and does not interfere with the patient / subject's activities during the daytime or nighttime sleep. 2. Blood pressure is elevated in patients with OSA and falls during treatment with CPAP. 3\. The renal treatment of salt and water is abnormal in OSA, improved during treatment with CPAP. 4\. Quality of life improves during treatment with CPAP

Detailed description

Approximately 20 patients with hypertension and moderate to severe OSA are treated with CPAP 3 months to examine the treatment effect on blood pressure throughout the day, but especially nocturnal, renal treatment of salt and water, and quality of life. Before and after 3 months of CPAP treatment is made central and peripheral 24-h ambulatory blood pressure monitoring, 24-h urine collection and blood samples.

Conditions

• Hypertension
• Obstructive Sleep Apnea

Interventions

Type	Name	Description
DEVICE	CPAP	3 months of CPAP treatment

Timeline

• Start date: 2014-02-01
• Primary completion: 2016-03-01
• Completion: 2017-03-01
• First posted: 2014-03-05
• Last updated: 2015-02-02

Locations

1 site across 1 country: Denmark