NCT02069054

Airway Inflammation and Remodeling in Asthma and COPD.

Relationship Between Airway Inflammation and Remodeling in Asthma and COPD Patients.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 72 (actual)
• Sponsor: Medical University of Warsaw · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

Asthma and chronic obstructive pulmonary disease (COPD) are inflammatory airway diseases. Although the clinical features of asthma and COPD may be similar, the pathogenesis of these diseases differs in many aspects. The aim of this study is: * to evaluate airway inflammation in asthma and COPD, * to evaluate airway remodeling in asthma and COPD as compared to healthy subjects, * to assess the relationship between markers of airway inflammation and airway remodeling in asthma and COPD patients. Material and methods: * mild to moderate asthma patients diagnosed in accordance with Global Initiative for Asthma (GINA) guidelines, * mild to moderate COPD patients diagnosed in accordance with Global initiative for chronic Obstructive Lung Disease (GOLD) guidelines, * healthy subjects as controls. Airway inflammation is assessed in induced sputum (IS), exhaled breath condensate (EBC), bronchoalveolar lavage fluid (BALF) and specimens from endobronchial forceps biopsy. Airway wall thickness is evaluated in high resolution computed tomography (HRCT), endobronchial ultrasound (EBUS) and basement membrane thickness (BMT) in biopsy specimens. We plan to compare airway inflammation and features of airway remodeling in asthma and COPD patients.

Conditions

• Asthma
• COPD

Timeline

• Start date: 2012-09-01
• Primary completion: 2015-05-01
• Completion: 2015-08-01
• First posted: 2014-02-21
• Last updated: 2016-04-27

Locations

1 site across 1 country: Poland