NCT02062879

Ketamine Patient-Controlled Analgesia for Acute Pain

Ketamine Patient-Controlled Analgesia for Acute Pain in Native Airway Multiple and Orthopedic Trauma Patients: A Randomized, Active Comparator, Blinded Trial

• Status: Terminated
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Cincinnati · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will compare ketamine and hydromorphone as alternative patient-controlled interventions for trauma-related pain. Patients receiving ketamine PCA are expected to require less total and breakthrough opioid and to have similar or improved objective pain scores. Patients receiving ketamine are also expected to have shorter duration of supplemental oxygen requirement, fewer episodes of oxygen desaturation, improved pulmonary toilet, lower use of antiemetics, and shorter times to first bowel movement. Ketamine is further expected to be associated with decreased intensive care unit and hospital lengths of stay, faster time to maximum allowable ambulation, decreased opioid dosage at discharge, and lower report of chronic pain syndromes.

Conditions

• Acute Pain
• Multiple Trauma
• Fractures

Interventions

Type	Name	Description
DRUG	Ketamine	Ketamine administered as patient-controlled analgesia.
DRUG	Hydromorphone	Hydromorphone administered as patient-controlled analgesia.

Timeline

• Start date: 2014-04-01
• Primary completion: 2016-06-01
• Completion: 2016-06-01
• First posted: 2014-02-14
• Last updated: 2017-09-21
• Results posted: 2017-09-21

Locations

1 site across 1 country: United States