NCT02025075

Hemodynamic and Respiratory Variations During Laparoscopic Surgery With and Without Deep Neuromuscular Blockade.

A Prospective, Double-blind, Randomized, Crossover Design Study to Compare the Hemodynamic and Respiratory Variations During Laparoscopic Surgery in Patients With and Without Deep Neuromuscular Blockade.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 37 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to investigate the effect of depth of neuromuscular block (NMB) on global and regional (dependent versus nondependent) respiratory mechanics during laparoscopic surgery. Furthermore, we will investigate if the level of NMB influences intraoperative hemodynamic and cerebral oxygenation.

Conditions

• Intraoperative Complications
• Postoperative Complications
• Laparoscopy
• Surgical Complications From General Anesthesia
• Ventilator-Induced Lung Injury

Interventions

Type	Name	Description
DRUG	Rocuronium	Rocuronium 0.6 - 1.2 mg/kg with the dose adjusted to achieve 1-2 post-tetanic counts (Deep NMB) or 1-2 twitches in the train-on-four (Moderate NMB).

Timeline

• Start date: 2014-01-01
• Primary completion: 2015-10-01
• Completion: 2015-10-01
• First posted: 2013-12-31
• Last updated: 2017-05-30
• Results posted: 2017-05-30

Locations

1 site across 1 country: United States