NCT02022280

Effect of Proton Pump Inhibitors on Endothelial Function

Do Proton Pump Inhibitors (PPIs) Increase Cardiovascular Risk? Effect of PPIs on Endothelial Function and ADMA.

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

In this randomized controlled crossover study, the investigators propose to test the hypothesis that proton pump inhibitors (PPIs) increase plasma levels of asymmetric dimethylarginine (ADMA), which is a marker of endothelial dysfunction. The authors propose to evaluate ADMA concentrations and vascular function analysis in healthy volunteers and adults with a history of cardiovascular disease given PPI vs placebo for four weeks each.

Conditions

• Endothelial Dysfunction

Interventions

Type	Name	Description
DRUG	Lansoprazole
DRUG	Placebo	Vitamin pill

Timeline

• Start date: 2013-03-01
• Primary completion: 2014-05-01
• Completion: 2014-05-01
• First posted: 2013-12-27
• Last updated: 2022-08-23

Locations

1 site across 1 country: United States