NCT02019459

Very Low Nicotine Cigarettes in Smokers With Schizophrenia

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: Brown University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Smokers with serious mental illness including those with schizophrenia and bipolar disorder infrequently attempt and attain sustained smoking abstinence and have a 25-year shorter lifespan due to smoking-related illness. This study will examine whether reducing the nicotine content of cigarettes to non-addicting levels is a viable method of reducing smoking in smokers with serious mental illness. Smokers will be randomized to one of two experimental conditions: 1) very low nicotine content (VLNC) cigarettes or 2) normal nicotine content (NNC) cigarettes. Participants will be assessed for patterns of tobacco use, biomarkers of exposure, subjective responses (e.g., satisfaction, craving, withdrawal symptoms), psychiatric symptoms, cognitive performance, smoking cue reactivity and smoking topography.

Conditions

• Tobacco Dependence

Interventions

Type	Name	Description
OTHER	Very low nicotine content cigarettes
OTHER	standard nicotine content cigarettes

Timeline

• Start date: 2014-11-17
• Primary completion: 2017-08-31
• Completion: 2017-08-31
• First posted: 2013-12-24
• Last updated: 2018-04-09

Locations

1 site across 1 country: United States