NCT02018185

Study of Magnetic Brain Stimulation in Treatment of Obsessive Compulsive Disorder

The Efficacy of Deep Repetitive Transcranial Magnetic Stimulation in Treatment of Obsessive Compulsive Disorder, a Double Blind Randomized Clinical Trial

• Status: Suspended
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of Manitoba · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

In a preliminary pilot study, the investigators tested the efficacy of rTMS over the medial prefrontal cortex in symptom profiles of obsessive compulsive disorder (OCD) patients. This study revealed considerable benefit in using rTMS for the treatment of OCD. In the current proposal, in a randomized clinical trial, the investigators aim to further evaluate the efficacy of rTMS in OCD in a larger sample size and for a longer period. Studies into the efficacy of rTMS in other psychiatric disorders such as depression have consistently shown that extension of the treatment to four weeks significantly increased the effect size. In the pilot study, the investigators applied rTMS for only two weeks. Although all patients consistently showed improvement in their symptoms, none of them showed complete remission of their OCD. Here, the investigators hypothesize that longer duration of rTMS treatment will have greater benefit in OCD symptom reduction.

Detailed description

The purpose of study is to examine the efficacy of rTMS over the medial prefrontal cortex in the treatment of OCD. rTMS will be provided to OCD patients in a randomized double blind controlled setting, and the investigators hypothesize that in this setting the treatment group would still show significant improvement in OCD symptoms as compared to the sham group. rTMS will be applied for four weeks on OCD patients and the investigators will assess improvement after four weeks of rTMS. The investigators hypothesize that patients will show significantly greater improvement after four weeks of rTMS vs. two weeks of rTMS.

Conditions

• Obsessive Compulsive Disorder

Interventions

Type	Name	Description
DEVICE	Transcranial Magnetic Stimulation	A non-invasive method for brain stimulation
DEVICE	Sham Transcranial Magnetic Stimulation	Sham stimulation of the brain.

Timeline

• Start date: 2014-01-01
• Primary completion: 2018-12-01
• Completion: 2021-08-01
• First posted: 2013-12-23
• Last updated: 2021-03-23

Locations

1 site across 1 country: Canada