NCT02012335

Ketamine Use in Electroconvulsive Therapy

Ketamine Use in Electroconvulsive Therapy: Clinical, Cognitives and Neurotrophic Outcomes

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Hospital de Clinicas de Porto Alegre · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether combination of ketamine plus electroconvulsive therapy improves depressive symptoms decreasing cognitive side effects.

Detailed description

This study will compare the clinical response to brief pulse ECT with infusion of ketamine 0.5 mg/kg versus brief pulse electroconvulsive therapy with infusion of placebo (saline) in major depression. We also will compare levels of cognitive impairment among these groups, compare levels of quality of life among these groups, compare levels of BDNF among these groups. We also will study if levels of 25-hydroxyvitamin D are associated with cognitive impairment in subjects undergoing ECT.

Conditions

• Depression

Interventions

Type	Name	Description
DRUG	ECT + Ketamine	Brief pulse ECT with 0.05 mg/kg ketamine infusion in each session

Timeline

• Start date: 2014-01-01
• Primary completion: 2016-01-01
• Completion: 2016-01-01
• First posted: 2013-12-16
• Last updated: 2015-03-19

Locations

1 site across 1 country: Brazil