Trials / Completed
CompletedNCT02009826
Psychosis-Associated Neuroinflammation in Schizophrenia
Phase 0 Clinical Protocol: A Longitudinal and Multimodal Exploratory Study to Evaluate a Neuroinflammatory Hypothesis in Patients With Schizophrenia Compared to Young Healthy Subjects
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 106 (actual)
- Sponsor
- Universiteit Antwerpen · Academic / Other
- Sex
- All
- Age
- 18 Years – 40 Years
- Healthy volunteers
- Accepted
Summary
Previous research has suggested central nervous system inflammatory activity to be critically involved in disease development and progression in schizophrenia, with a complex interplay of inflammatory mechanisms leading to the development of brain abnormalities and medical symptoms related to schizophrenia. However, the mutual interactions of different inflammatory pathways and their relation to disease course have not been sufficiently studied. This study therefore aims to explore the interaction of neuroinflammatory mechanisms in patients with schizophrenia and to assess whether the inflammatory activity in schizophrenia is state-dependent and occurs mainly during psychotic episodes.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| RADIATION | [18F]-PBR111 Positron Emission Tomography (PET) | \[18F\]-PBR111 radioligand to assess binding to TSPO |
| BEHAVIORAL | Cognitive and psychomotor tasks | Cognitive and psychomotor tasks on digitizing tablet |
| BIOLOGICAL | Blood sampling | Blood sampling for peripheral inflammatory and neurotoxicity markers |
Timeline
- Start date
- 2013-11-01
- Primary completion
- 2017-02-01
- Completion
- 2017-02-01
- First posted
- 2013-12-12
- Last updated
- 2017-08-31
Locations
3 sites across 1 country: Belgium
Source: ClinicalTrials.gov record NCT02009826. Inclusion in this directory is not an endorsement.