NCT02006095

Neuroimaging Correlates of Memory Decline Following Carotid Interventions

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 207 (actual)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

Carotid revascularization can significantly reduce the risk of stroke in patients with severe carotid stenosis; however, it has been associated with cognitive decline in 25% of the older adults who undergo the procedure. Characterizing risk factors for cognitive decline following carotid interventions and individualizing treatment strategy based on those risks can minimize procedure-associated cognitive dysfunction. Neuroimaging techniques that characterize white matter integrity and regional hypoperfusion have the potential to provide sensitive brain structure indicators that may be associated with memory decline following revascularization procedures. In this protocol, we hope to determine how cerebral blood flow and baseline white matter abnormality in the vulnerable region modify the frequency and cognitive effect of microembolization following carotid revascularization procedures.

Conditions

• Carotid Artery Stenosis

Interventions

Type	Name	Description
OTHER	Magnetic resonance imaging	arterial spin labeling, diffusion tensor imaging, and diffusion weighted imaging sequences will be used
BEHAVIORAL	Neuropsychological testing

Timeline

• Start date: 2012-11-01
• Primary completion: 2018-04-01
• Completion: 2018-04-01
• First posted: 2013-12-09
• Last updated: 2022-08-29

Locations

1 site across 1 country: United States