NCT01998100

Maximizing Treatment Outcome in Post-Traumatic Stress Disorder (PTSD)

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: University of Texas at Austin · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the efficacy of exercise + therapy to therapy alone to determine if they can improve the effects of prolonged exposure therapy (PE) in reducing symptoms of anxiety associated with Post-traumatic Stress Disorder (PTSD). In addition the two strategies (i.e., exercise + therapy and therapy alone condition) will be compared in terms of levels of brain-derived neurotrophic factor (BDNF). BDNF is a protein that helps to support the survival of existing neurons and stimulate the growth of new neurons and synapses. BDNF is important to learning and memory in general and therefore may be associated with the learning and memory as it relates to PE and corresponding symptoms PTSD improvement.

Conditions

• Post-Traumatic Stress Disorder

Interventions

Type	Name	Description
BEHAVIORAL	Prolonged Exposure	75-90 minute weekly psychotherapy sessions x 12 weeks, focused on gradually confronting distressing trauma-related memories and reminders.
BEHAVIORAL	Exercise	30 minutes of moderate-intensity treadmill exercise prior to the Prolonged Exposure

Timeline

• Start date: 2010-09-01
• Primary completion: 2013-07-01
• Completion: 2013-07-01
• First posted: 2013-11-28
• Last updated: 2015-12-29

Locations

2 sites across 1 country: United States