NCT01984957

Differential Study of Muscle Transcriptome

Differential Study of Muscle Transcriptome in Patients With Neuromuscular Disease and Control Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

To isolate biomarkers of ALS in muscle

Detailed description

At present, there is no validated biological diagnostic marker for amyotrophic lateral sclerosis (ALS). The main objective of the study is to isolate a set of genes that are specifically dysregulated in muscle from ALS patients. Gene profiling in muscle will be compared between ALS patients and patients with other motor neuron diseases (SMA and SBMA)

Conditions

• ALS
• SMA
• SBMA

Interventions

Type	Name	Description
PROCEDURE	Muscle biopsy	open muscular biopsy of the deltoid under local anaesthesia

Timeline

• Start date: 2013-01-01
• Primary completion: 2015-01-01
• Completion: 2015-01-01
• First posted: 2013-11-15
• Last updated: 2015-03-23

Locations

1 site across 1 country: France