NCT01969617

Effects of Nalmefene After Single Dose on the Blood Oxygen Level Dependent (BOLD) fMRI Signal in the Ventral Striatum to Reward Responding in the Monetary Incentive Delay Task (MIDT), in Non-treatment Seeking Subjects With Alcohol Dependence Following Alcohol Challenge

Interventional, Randomized, Double-blind, Cross-over, Placebo-controlled Study to Investigate the Effects of Nalmefene After Single Dose on the Blood Oxygen Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Signal in the Ventral Striatum to Reward Responding in the Monetary Incentive Delay Task (MIDT), in Non-treatment Seeking Subjects With Alcohol Dependence Following Alcohol Challenge

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: H. Lundbeck A/S · Industry
• Sex: Male
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

To contribute to the understanding of the underlying neurobiological mechanism behind the interaction of alcohol and nalmefene

Conditions

• Alcohol Dependence

Interventions

Type	Name	Description
DRUG	Nalmefene 18 mg, then placebo	One single oral dose Nalmefene on Day 1 and Placebo on Day 8
DRUG	Placebo, then Nalmefene 18 mg	One single oral dose Placebo on Day 1 and Nalmefene on Day 8

Timeline

• Start date: 2013-11-01
• Primary completion: 2014-10-01
• First posted: 2013-10-25
• Last updated: 2014-11-11

Locations

1 site across 1 country: United Kingdom