NCT01957098

The Effects of L-Arabinose and D-xylose on Intestinal Sucrase Activity in Man

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate the effect of L-arabinose and D-xylose in a sugar-rich drink on intestinal sucrase activity in healthy volunteers by measuring postprandial blood glucose and insulin, and selected intestinal hormonal responses to increasing doses of L-arabinose and D-xylose.

Detailed description

Based on previous scientific results we hypotesize, that pentoses decreases the demand for insulin in metabolizing a given dose of sucrose.

Conditions

• Insulin Resistance

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Placebo comparator: 0% pentose	14 healthy subjects participated in a randomized double-blinded cross-over study based on four single tests. Sucrose containing drinks were supplemented with two different doses of D-xylose and in addition one dose of L-arabinose was included for comparison with earlier studies. Blood was collected fasting and for 3-h postprandially. Appetite sensations and energy intake were registered. Gastrointestinal symptoms were monitored for 24 hours
DIETARY_SUPPLEMENT	Active comparator: 4% D-xylose
DIETARY_SUPPLEMENT	Active comparator: 8% D-xylose
DIETARY_SUPPLEMENT	Active comparator: 8% L-arabinose

Timeline

• Start date: 2006-10-01
• Primary completion: 2007-01-01
• Completion: 2007-05-01
• First posted: 2013-10-08
• Last updated: 2013-10-08

Locations

1 site across 1 country: Denmark