Trials / Unknown
UnknownNCT01949233
The Oxford Marfan Trial
A Randomised, Double-blind, Placebo-controlled Pilot Trial of Irbesartan, Doxycycline and a Combination on Markers of Vascular Dysfunction in the Marfan Syndrome, Using Cardiovascular Magnetic Resonance Imaging
- Status
- Unknown
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 56 (estimated)
- Sponsor
- University of Oxford · Academic / Other
- Sex
- All
- Age
- 13 Years
- Healthy volunteers
- Not accepted
Summary
The primary objective of the trial is to estimate the effects of allocation to irbesartan, or doxycycline, or a combination of both irbesartan and doxycycline, compared with placebo, on measures of elastic function of the aorta in people with the Marfan syndrome and enlargement of the aorta.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Irbesartan 150-300mg capsules daily for 6 months | |
| DRUG | Doxycycline 100-200mg capsules daily for 6 months | |
| DRUG | Doxycycline placebo capsules daily for 6 months | |
| DRUG | Irbesartan placebo capsules daily for 6 months |
Timeline
- Start date
- 2013-10-01
- Primary completion
- 2015-10-01
- Completion
- 2017-12-01
- First posted
- 2013-09-24
- Last updated
- 2015-06-09
Locations
2 sites across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT01949233. Inclusion in this directory is not an endorsement.