NCT01947036

T and B Cell Responses in Autoimmune Diseases

T and B Cell Responses Across Autoimmune Diseases

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 68 (actual)
• Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) · NIH
• Sex: All
• Age: 8 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The study aims to establish whether defects in immune cell function are shared across multiple autoimmune diseases and whether those problems match to similar genes in the cells.

Detailed description

This is a non-randomized, multi-center clinical research study. Subjects who are healthy or have a confirmed or suspected diagnosis of type 1diabetes, multiple sclerosis, psoriasis, Crohn's disease, or rheumatoid arthritis will be asked to donate a blood sample. No follow-ups are planned. Investigators will: * evaluate immune cells from subjects enrolled in this study and match the differences to types of immune cells known to cause autoimmune diseases * investigate a particular disease pathway: the IL23R signaling cascade.

Conditions

• Type 1 Diabetes Mellitus
• Multiple Sclerosis
• Arthritis, Rheumatoid
• Crohn's Disease
• Psoriasis

Timeline

• Start date: 2014-01-01
• Primary completion: 2015-10-01
• Completion: 2015-10-01
• First posted: 2013-09-20
• Last updated: 2016-10-26

Locations

6 sites across 1 country: United States