NCT01931527

Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status

Effect of Plasma Uric Acid on Insulin Sensitivity, Endothelial Function and Inflammation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to learn more about what is the effect of uric acid on oxidative stress and on the way the body metabolizes sugar in obese people. Understanding this may lead to better diseases such as diabetes.

Detailed description

It has been hypothesized that oxidative stress is involved in the pathogenesis of insulin resistance associated with obesity. Circulating uric acid (UA) is the body's major endogenous plasma antioxidant. Therefore, the investigators evaluated whether alterations in serum UA concentration affect: 1) systemic and skeletal muscle oxidative stress, 2) total antioxidant capacity, and 4) skeletal muscle insulin sensitivity during a hyperinsulinemic-euglycemic clamp.

Conditions

• Obesity
• Metabolic Syndrome
• Hyperuricemia

Interventions

Type	Name	Description
DRUG	Rasburicase	one single infusion of rasburicase (0.19 mg/kg FFM) infused over 30 min

Timeline

• Start date: 2006-07-01
• Primary completion: 2008-06-01
• Completion: 2012-11-01
• First posted: 2013-08-29
• Last updated: 2018-08-14
• Results posted: 2015-05-15

Locations

1 site across 1 country: United States