NCT01928719

Reduced Nicotine Content Cigarettes in Smokers of Lower Socioeconomic Status

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 280 (actual)
• Sponsor: Milton S. Hershey Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The overall goal of this study is to address the question of whether progressively lowering nicotine content in cigarettes can reduce or eliminate nicotine dependence in smokers of low socioeconomic status

Detailed description

To address the question of whether progressively lowering nicotine content in cigarettes can reduce or eliminate nicotine dependence in low socioeconomic smokers, we will randomize smokers to either an Reduced Nicotine Content group with a gradual step-wise reduction in nicotine from 11 mg to 0.2 mg per cigarette in five 3-wk stages, or a control group with nicotine content similar to their preferred usual brand of cigarettes. Overall, we hypothesize that low socioeconomic smokers who switch to progressively lower nicotine cigarettes will initially alter their smoking behavior to compensate for lower nicotine until cigarette nicotine yields become so low that complete compensation becomes too difficult. At that point, smokers will either drop-out or continue to smoke the reduced nicotine content cigarettes but with incomplete compensatory behaviors.

Conditions

• Tobacco Dependence

Interventions

Type	Name	Description
DRUG	Reduced Nicotine Content Cigarettes	Cigarettes contain 11.6, 7.4, 3.3, 1.4, 0.7, and 0.2 mg nicotine per cigarette
DRUG	Same Nicotine Content Cigarettes	about 11.6 mg nicotine per cigarette

Timeline

• Start date: 2015-09-09
• Primary completion: 2018-01-05
• Completion: 2018-02-23
• First posted: 2013-08-27
• Last updated: 2019-05-01
• Results posted: 2019-03-12

Locations

2 sites across 1 country: United States