Trials / Unknown
UnknownNCT01918488
Increased Activity of a Renal Salt Transporter (ENaC) in Diabetic Kidney Disease
Increased Activity of the Epithelial Sodium Channel (ENaC) in Diabetic Nephropathy
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- Sponsor
- University of Southern Denmark · Academic / Other
- Sex
- All
- Age
- 18 Years – 90 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of the study is to determine whether a diuretic drug called amiloride is capable of increasing renal salt excretion and thereby decrease blood pressure in diabetic patients with kidney disease. Our hypothesis states that amiloride is capable of reducing blood pressure in these patients and thus decrease the cardiovascular risk associated with diabetic kidney disease.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | Standardized salt diet | 200 mmol NaCl per day given as three meals daily for 4 consecutive days. |
| DRUG | Amiloride | Amiloride tablet 20 mg two times daily (morning and afternoon) for two consecutive days. |
Timeline
- Start date
- 2013-10-01
- Primary completion
- 2014-12-01
- First posted
- 2013-08-07
- Last updated
- 2013-10-16
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT01918488. Inclusion in this directory is not an endorsement.