NCT01903707

Cognitive Remediation in Schizophrenia

Cognitive Remediation in Schizophrenia: Effects on Brain Structure, Brain Function and Social Outcome.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: University of Dublin, Trinity College · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The aim of this project is to undertake a randomized placebo controlled trial of cognitive remediation therapy (CRT) that focuses on working memory training in a sample of community based patients with chronic schizophrenia or other psychoses. Cognitive deficits are a problem for many people with schizophrenia. This study will use computerized cognitive remediation training (which the participant can carry out at home) over a period of a few months.

Detailed description

The aim of this project is to undertake a randomized placebo controlled trial of cognitive remediation therapy (CRT) that focuses on working memory training in a sample of community based patients with schizophrenia. Pre and Post neuropsychological assessment and Magnetic Resonance Imagery (MRI) will be used to determine the effects of CR training on 1. Neuropsychological performance 2. Brain Structure using voxel-based morphometry (VBM) 3. Brain function using functional MRI (fMRI) 4. Social and occupational functioning The cognitive remediation intervention is a computerised programme whose training level is dynamically varied to suit participants individual ability level. Motivation to learn and generalization to real world function are a particular focus of the intervention and are supported with ongoing therapist interaction in addition to personal training.

Conditions

• Schizophrenia
• Psychosis

Interventions

Type	Name	Description
OTHER	Cognitive Remediation Therapy	Computerised training undertaken for approximately 30 minutes per day, 5 days per week for 8 weeks
OTHER	Placebo comparator	Participant meets the therapist once per week but does not carry out the CRT intervention. (Participants are subsequently offered the chance to carry out the CRT intervention post study if they so wish).

Timeline

• Start date: 2013-05-01
• Primary completion: 2015-06-01
• Completion: 2015-10-01
• First posted: 2013-07-19
• Last updated: 2014-12-05

Locations

1 site across 1 country: Ireland