NCT01883453

A Nasal Spray With Glucose Oxidase as a Treatment of Common Cold

A Double Blinded Clinical Study Aiming to Shorten an Episode of Common Cold When the Treatment is Started at the Onset of an Episode of Common Cold

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 146 (actual)
• Sponsor: Umeå University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Healthy persons are invited to participate in the study and are given a home protocol (WURSS21), nasal spray and a sample pin. The included persons are told to make a nasopharyngeal sampling from the nose when they are sure that they have caught a common cold. After the sampling they start to spray and also fill in the records daily. The aim of the study is to investigate whether a nasal spray with glucose oxidase could shorten an episode of common cold.

Detailed description

Persons working in a military unit in Boden and persons connected to the Department of Sports Medicine in Umeå were invited to participate in this study. Only persons older than 18 years was included in the study. The persons included received one bottle of study medicine, a home protocol (WURSS 21) and a viral sampling kit. Whenever the included persons were sure that they had received an episode of common cold they were told to perform a viral sampling from the nose, fill in the protocol and start to use the nasal spray several times daily for one week. The treatment was either a) a saline solution with 5% glucose or b) a saline solution with 200U/ml of glucose oxidase and 5%glucose (active treatment group). The combination of glucose oxidase and glucose produces an acid environment, imitating the effect of the normal nasal flora and Human Rhinoviruses are sensitive to an acid environment. After one week of treatment and daily records of the WURSS 21 protocol the persons returned the spray bottles (Bag-on-Valve), the virus vials and the protocols. A total of 146 persons were included in the study and 98 persons returned protocols.

Conditions

• Common Cold

Interventions

Type	Name	Description
DEVICE	Glucose oxidase+5%glucose	A hydrogen peroxide producing enzyme
DEVICE	Saline+5%glucose	Isotonic saline + 5% glucose in a bag-on-valve nasal spray device

Timeline

• Start date: 2013-01-01
• Primary completion: 2013-05-01
• Completion: 2013-09-01
• First posted: 2013-06-21
• Last updated: 2015-11-09
• Results posted: 2015-11-09

Locations

2 sites across 1 country: Sweden