NCT01883440

Glucose Oxidase as Treatment Against Common Cold

A Placebo Controlled Study With a Nasal Spray Containing Glucose Oxidase, Aiming to Induce a Faster Recovery From an Episode of Common Cold

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Krister Tano · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Glucose oxidase is a hydrogen peroxide producing enzyme, which also is present in honey. Human rhinoviruses are sensitive to the action of hydrogen peroxide, which is documented in laboratory studies. In the present study we aim to investigate if a nasal spray with glucose oxidase could treat a common cold, when the treatment is started even after the onset of the symptoms. The study is randomized and placebo controlled.

Detailed description

Persons that are convinced of that they have caught an episode of common cold can be included into the study within 24 hours after the onset of symptoms. Before they start the treatment with the nasal spray they perform a viral sample from the nose and also fill in the WURSS-21 protocol. After this the persons spray with glucose oxidase+glucose/only saline+glucose 5 times the first day and thereafter 3 times daily for a total treatment of one week. Every day the included persons fill in the WURSS-21 protocol.

Conditions

• Common Cold

Interventions

Type	Name	Description
DRUG	Glucose oxidase + glucose	Isotone saline + 200U/ml of glucose oxidase + 5% of glucose in a bag on valve nasal spray device
DRUG	Saline+glucose	Placebo arm

Timeline

• Start date: 2013-01-01
• Primary completion: 2013-08-01
• Completion: 2013-09-01
• First posted: 2013-06-21
• Last updated: 2016-01-27
• Results posted: 2016-01-27

Locations

1 site across 1 country: Sweden